what is the non-null genotype with regard to disease association
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A null allele is a mutant copy of a gene that completely lacks that gene's normal function.

One example of a null allele is the 'O' blood type allele in the human A, B and O blood type system. The alleles for the A-antigen and B-antigen are co-dominant, thus they are both phenotypically expressed if both are present. The allele for O blood type, however, is a mutated version of the allele for the A-antigen, with a single base pair change due to genetic mutation. The protein coded for by the O allele is enzymatically inactive and therefore the O allele is expressed phenotypically in homozygous OO individuals as the lack of any blood antigen. Thus we may consider the allele for the O blood type as a null allele.

So therefore, a genotype, which represents an organisms genes, can contain no non alleles and be considered a non-null genotype.

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